Tapering off benzodiazepines

Xanax, Klonopin, Ativan and Valium should never be stopped suddenly. A supervised, gradual reduction is both safer and far more comfortable than trying to white-knuckle it.

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The basics

What benzodiazepines are, and why they are prescribed

Benzodiazepines calm the nervous system. They are prescribed for anxiety and panic disorder, for short-term insomnia, for muscle spasm, for seizures, and to manage alcohol withdrawal. They work quickly and they work well, which is part of the problem: a medication that reliably takes the edge off within twenty minutes is a hard one to stop taking.

Almost every clinical guideline treats them as a short-term option — weeks, not years. In practice a great many people have been taking one daily for a decade or more, often at a dose that no longer does what it did at the start.

In 2020 the FDA added a boxed warning to the entire class covering abuse, misuse, addiction, physical dependence and withdrawal reactions. That warning is not a reason to stop abruptly. It is a reason to stop carefully, with a provider.

Generic and brand names

Z-drugs such as zolpidem (Ambien) and eszopiclone (Lunesta) act on the same receptor system and behave similarly on withdrawal, but they are a separate class — they have their own page.

Generic nameCommon brand namesTypically prescribed for
AlprazolamXanax, Xanax XRAnxiety, panic disorder
ClonazepamKlonopinPanic disorder, seizure disorders
LorazepamAtivanAnxiety, sedation before procedures, status epilepticus
DiazepamValiumAnxiety, muscle spasm, alcohol withdrawal, seizures
TemazepamRestorilShort-term treatment of insomnia
ChlordiazepoxideLibriumAnxiety, alcohol withdrawal
ClorazepateTranxeneAnxiety, seizure disorders
TriazolamHalcionShort-term treatment of insomnia
OxazepamGeneric only in the USAnxiety, alcohol withdrawal

What long-term use can look like

Tolerance is the pattern most patients recognize first: the dose that used to settle things no longer quite does, and the day between doses gets harder rather than easier.

Tolerance

The same dose does less over time. Some people find their anxiety is worse on the medication than it was before they started it — an effect that only becomes visible once the dose comes down.

Memory and concentration

Difficulty forming new memories, word-finding trouble, and a general sense of mental fog that is often attributed to age or stress.

Daytime sedation

Drowsiness, slowed reactions and impaired driving, particularly with the longer-acting medications in this class.

Falls and fractures

A well-established risk in older adults, and one of the main reasons deprescribing guidelines single this class out.

Rebound between doses

Anxiety, sweating or agitation that arrives before the next dose is due, and that is relieved by taking it — a sign of physical dependence rather than of the original condition.

Interaction with opioids

Taken together, benzodiazepines and opioids substantially increase the risk of dangerous respiratory depression. If you are on both, say so at intake.

What stopping abruptly can feel like

This is the class where abrupt discontinuation is genuinely dangerous. Do not stop a benzodiazepine on your own, and do not let a prescription run out unplanned — talk to a provider first.

Seizures

Abrupt withdrawal from a benzodiazepine can cause seizures, including in people who have never had one. This is the reason a supervised taper is not optional.

Severe rebound anxiety and panic

Anxiety that is markedly worse than anything before the medication started, often with a sense of dread that feels physical.

Insomnia

Little or no sleep for several nights, which then makes every other symptom harder to bear.

Tremor, sweating and palpitations

Shaking hands, drenching sweats and a racing or pounding heart.

Sensory hypersensitivity

Light, sound and touch becoming painfully intense; tingling or burning skin sensations.

Confusion and perceptual changes

Disorientation, derealization, and in severe cases delirium. A medical emergency, and a reason to seek help immediately rather than push through.

Before you change anything

This page is general information about a group of medications. It is not medical advice about you, and it is not a reason to change a dose on your own.

Several of the medications Prescriby Health tapers can be dangerous to stop abruptly. If you are in withdrawal now, contact your prescriber or an urgent care service today. If you feel unsafe, call 911. For mental-health crisis support in the US, call or text 988.

Our approach

How we taper benzodiazepines

Slowly, and in proportion. The dose comes down in planned percentage steps rather than fixed milligram cuts, so the reduction stays the same size relative to what you are actually taking. Where it helps, your provider may first move you from a short-acting benzodiazepine to a longer-acting one, which smooths out the peaks and troughs that make the process feel worse than it needs to.

There is no prize for finishing quickly. Holding a dose for a few extra weeks because a step was hard is a normal part of a successful taper, not a setback. We plan for holds from the start.

We take over prescribing the benzodiazepine for the duration of the taper, so the supply is predictable and you are never in the position of rationing tablets. You log symptoms between visits in the Prescriby app, and follow-ups are as frequent as your taper needs — weekly at the harder stages if that is what it takes.

Learn more

Related reading on tapering and on how the program works.

How the tapering program works

Intake, the taper schedule, follow-up intervals, cost, and who the program is and is not right for.

See the program
All medications we taper

The six groups we work with, with generic and brand names for each.

Browse medications
News and articles

Clinical insight, patient stories and company news from Prescriby Health.

Read the blog

Questions about benzodiazepines

Ready to talk about benzodiazepines?

Tell us the name on the box and how long you have been taking it. We will tell you what a taper would look like.

You do not need a referral. Providers are welcome to refer directly.